2I32
Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Anti-Silencing Factor 1 paralog a | polymer | 182 | 20837.1 | 2 | UniProt (Q9Y294) Pfam (PF04729) | Homo sapiens (human) | ASF1a protein, ASF1 anti-silencing function 1 homolog A, Hypothetical protein FLJ22085, Anti-silencing function 1A, CGI-98 protein, CIA |
| 2 | C, D (E, F) | Histone Regulatory homolog A | polymer | 57 | 6216.0 | 2 | UniProt (P54198) | Homo sapiens (human) | HIRA protein, TUP1-like enhancer of split protein 1 |
| 3 | E, F, G, H (A, B, E, F) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 157 (UniProt: Q9Y294)
E, F: 425 - 472 (UniProt: P54198)
| PDB | External Database | Details |
|---|---|---|
| Met -24 | - | cloning artifact |
| Gly -23 | - | cloning artifact |
| Ser -22 | - | cloning artifact |
| Ser -21 | - | cloning artifact |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| Asp -14 | - | cloning artifact |
| Tyr -13 | - | cloning artifact |
| Asp -12 | - | cloning artifact |
| Ile -11 | - | cloning artifact |
| Pro -10 | - | cloning artifact |
| Thr -9 | - | cloning artifact |
| Thr -8 | - | cloning artifact |
| Glu -7 | - | cloning artifact |
| Asn -6 | - | cloning artifact |
| Leu -5 | - | cloning artifact |
| Tyr -4 | - | cloning artifact |
| Phe -3 | - | cloning artifact |
| Gln -2 | - | cloning artifact |
| Gly -1 | - | cloning artifact |
| Ser 0 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Ser 416 | - | cloning artifact |
| Glu 417 | - | cloning artifact |
| Asn 418 | - | cloning artifact |
| Leu 419 | - | cloning artifact |
| Tyr 420 | - | cloning artifact |
| Phe 421 | - | cloning artifact |
| Gln 422 | - | cloning artifact |
| Gly 423 | - | cloning artifact |
| Ser 424 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 54106.1 | |
| All* | Total formula weight | 54106.1 |
