2I1M

cFMS tyrosine kinase (tie2 KID) in complex with an arylamide inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Macrophage colony-stimulating factor 1 receptor	polymer	333	37613.1	1	UniProt (P07333) Pfam (PF07714)	Homo sapiens (human)	cFMS Receptor Tyrosine Kinase, CSF-1-R, Fms proto-oncogene, c-fms, CD115 antigen
2	B (A)	5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE	non-polymer		339.4	1	Chemie (5CN)
3	C (A)	water	water		18.0	176	Chemie (HOH)

Sequence modifications

A: 538 - 678 (UniProt: P07333)

PDB	External Database	Details
Gly 535	-	expression tag
Val 536	-	expression tag
Asp 537	-	expression tag

A: 753 - 922 (UniProt: P07333)

PDB	External Database	Details
Ser 679	-	SEE REMARK 999
Arg 680	-	SEE REMARK 999
Val 681	-	SEE REMARK 999
Leu 682	-	SEE REMARK 999
Glu 683	-	SEE REMARK 999
Thr 684	-	SEE REMARK 999
Asp 685	-	SEE REMARK 999
Pro 686	-	SEE REMARK 999
Ala 687	-	SEE REMARK 999
Phe 688	-	SEE REMARK 999
Ala 689	-	SEE REMARK 999
Ile 690	-	SEE REMARK 999
Ala 691	-	SEE REMARK 999
Asn 692	-	SEE REMARK 999
Ser 693	-	SEE REMARK 999
Thr 694	-	SEE REMARK 999
Ala 697	-	SEE REMARK 999
Ser 698	-	SEE REMARK 999
Thr 699	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37613.1
Non-Polymers*	Number of molecules	1
	Total formula weight	339.4
All*	Total formula weight	37952.5

*Water molecules are not included.