2I0V

c-FMS tyrosine kinase in complex with a quinolone inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	cFMS tyrosine kinase	polymer	335	38064.5	1	UniProt (P07333) Pfam (PF07714)	Homo sapiens (human)
2	B (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	C (A)	6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE	non-polymer		336.8	1	Chemie (6C3)
4	D (A)	water	water		18.0	26	Chemie (HOH)

Sequence modifications

A: 538 - 678 (UniProt: P07333)

PDB	External Database	Details
Gly 535	-	expression tag
Val 536	-	expression tag
Asp 537	-	expression tag

A: 753 - 922 (UniProt: P07333)

PDB	External Database	Details
Arg 679	-	SEE REMARK 999
Pro 680	-	SEE REMARK 999
Pro 681	-	SEE REMARK 999
Gly 682	-	SEE REMARK 999
Leu 683	-	SEE REMARK 999
Glu 684	-	SEE REMARK 999
Tyr 685	-	SEE REMARK 999
Ser 686	-	SEE REMARK 999
Tyr 687	-	SEE REMARK 999
Asn 688	-	SEE REMARK 999
Pro 689	-	SEE REMARK 999
Ser 690	-	SEE REMARK 999
His 691	-	SEE REMARK 999
Asn 692	-	SEE REMARK 999
Pro 693	-	SEE REMARK 999
Glu 694	-	SEE REMARK 999
Glu 695	-	SEE REMARK 999
Gln 696	-	SEE REMARK 999
Leu 697	-	SEE REMARK 999
Ser 698	-	SEE REMARK 999
Ser 699	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	38064.5
Non-Polymers*	Number of molecules	2
	Total formula weight	432.8
All*	Total formula weight	38497.3

*Water molecules are not included.