2I0G

Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Estrogen receptor beta	polymer	257	29228.6	2	UniProt (Q92731) Pfam (PF00104) In PDB	Homo sapiens (human)	ER-beta
2	A, B	(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL	non-polymer		282.3	2	Chemie (I0G)
3		water	water		18.0	17	Chemie (HOH)

Sequence modifications

A, B: 256 - 505 (UniProt: Q92731)

PDB	External Database	Details
Met 249	-	cloning artifact
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag
His 255	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	58457.3
Non-Polymers*	Number of molecules	2
	Total formula weight	564.7
All*	Total formula weight	59022.0

*Water molecules are not included.