2I0G
Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor beta | polymer | 257 | 29228.6 | 2 | UniProt (Q92731) Pfam (PF00104) | Homo sapiens (human) | ER-beta |
| 2 | C, D (A, B) | (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL | non-polymer | 282.3 | 2 | Chemie (I0G) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 17 | Chemie (HOH) |
Sequence modifications
A, B: 256 - 505 (UniProt: Q92731)
| PDB | External Database | Details |
|---|---|---|
| Met 249 | - | cloning artifact |
| His 250 | - | expression tag |
| His 251 | - | expression tag |
| His 252 | - | expression tag |
| His 253 | - | expression tag |
| His 254 | - | expression tag |
| His 255 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58457.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 564.7 | |
| All* | Total formula weight | 59022.0 |
