2HYE
Crystal Structure of the DDB1-Cul4A-Rbx1-SV5V Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA damage-binding protein 1 | polymer | 1140 | 127117.5 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (human) | Damage-specific DNA-binding protein 1, UV-damaged DNA-binding factor, DDB p127 subunit, DDBa, UV-damaged DNA-binding protein 1, UV-DDB 1, Xeroderma pigmentosum group E- complementing protein, XPCe, XPE-binding factor, XPE-BF, X- associated protein 1, XAP-1 |
| 2 | B (B) | Nonstructural protein V | polymer | 222 | 23965.0 | 1 | UniProt (P11207) Pfam (PF14313) Pfam (PF13008) | Simian virus 5 | |
| 3 | C (C) | Cullin-4A | polymer | 759 | 87814.3 | 1 | UniProt (Q13619) Pfam (PF00888) Pfam (PF10557) | Homo sapiens (human) | CUL-4A |
| 4 | D (D) | RING-box protein 1 | polymer | 108 | 12290.0 | 1 | UniProt (P62877) Pfam (PF12678) | Homo sapiens (human) | Rbx1, Regulator of cullins 1, RING finger protein 75, ZYP protein |
| 5 | E, F, G, H, I (B, D) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) |
Sequence modifications
A: 1 - 1140 (UniProt: Q16531)
| PDB | External Database | Details |
|---|---|---|
| Tyr 422 | Asp 422 | conflict |
| Asp 898 | Glu 898 | conflict |
| Val 899 | Leu 899 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 251186.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 327.0 | |
| All* | Total formula weight | 251513.9 |
