2HY8
PAK1 complex with ST2001
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | 1 | Serine/threonine-protein kinase PAK 1 | polymer | 297 | 33301.2 | 1 | UniProt (Q13153) Pfam (PF00069) In PDB | Homo sapiens (human) | p21-activated kinase 1, PAK-1, P65-PAK, Alpha-PAK |
| 2 | 1 | (5S,6R,7R,9R)-12-HYDROXY-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[ B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE | non-polymer | 480.5 | 1 | Chemie (1ST) | |||
| 3 | water | water | 18.0 | 192 | Chemie (HOH) |
Sequence modifications
1: 249 - 545 (UniProt: Q13153)
| PDB | External Database | Details |
|---|---|---|
| Arg 299 | Lys 299 | engineered mutation |
| Glu 423 | Thr 423 | engineered mutation |
| Asp 503 | Glu 503 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33301.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 480.5 | |
| All* | Total formula weight | 33781.8 |
