2HWO
Crystal structure of Src kinase domain in complex with covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase Src | polymer | 286 | 32742.7 | 2 | UniProt (P00523) Pfam (PF07714) | Gallus gallus (chicken) | p60-Src, c-Src, pp60c-src |
| 2 | C, D (A, B) | N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE | non-polymer | 290.3 | 2 | Chemie (RBS) | |||
| 3 | E (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A, B: 251 - 533 (UniProt: P00523)
| PDB | External Database | Details |
|---|---|---|
| Gly 248 | - | cloning artifact |
| His 249 | - | cloning artifact |
| Met 250 | - | cloning artifact |
| Cys 345 | Ser 344 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65485.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 672.7 | |
| All* | Total formula weight | 66158.2 |
