2HWM

Crystal structure of Lys12Val/Cys117Val mutant of human acidic fibroblast growth factor at 1.60 angstrom resolution

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Heparin-binding growth factor 1	polymer	146	16652.7	2	UniProt (P05230) Pfam (PF00167) In PDB	Homo sapiens (human)	HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta
2	A, B	FORMIC ACID	non-polymer		46.0	4	Chemie (FMT)
3		water	water		18.0	268	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Val 12	Lys 27	engineered mutation
Val 117	Cys 132	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33305.4
Non-Polymers*	Number of molecules	4
	Total formula weight	184.1
All*	Total formula weight	33489.5

*Water molecules are not included.