2HWL

Crystal structure of thrombin in complex with fibrinogen gamma' peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Prothrombin	polymer	36	4096.5	2	UniProt (P00734) Pfam (PF09396) In PDB	Homo sapiens (human)	Coagulation factor II
2	B, D	Prothrombin	polymer	259	29694.1	2	UniProt (P00734) Pfam (PF00089) In PDB	Homo sapiens (human)	Coagulation factor II
3	P	Fibrinogen gamma' peptide	polymer	14	1803.6	1	UniProt (P02679) In PDB
4	B, D	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
5	D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
6		water	water		18.0	133	Chemie (HOH)

Sequence modifications

B, D: 16 - 247 (UniProt: P00734)

PDB	External Database	Details
Ala 77	Arg 436	engineered mutation

P: 413 - 426 (UniProt: P02679)

PDB	External Database	Details
Ptr 418	Tyr 444	modified residue
Ptr 422	Tyr 448	modified residue

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	69384.8
Non-Polymers*	Number of molecules	3
	Total formula weight	267.2
All*	Total formula weight	69652.0

*Water molecules are not included.