2HWL
Crystal structure of thrombin in complex with fibrinogen gamma' peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Prothrombin | polymer | 36 | 4096.5 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B, D (B, D) | Prothrombin | polymer | 259 | 29694.1 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | E (P) | Fibrinogen gamma' peptide | polymer | 14 | 1803.6 | 1 | UniProt (P02679) | ||
| 4 | F, H (B, D) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 5 | G (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | I, J, K, L, M (A, B, C, D, P) | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
B, D: 16 - 247 (UniProt: P00734)
P: 413 - 426 (UniProt: P02679)
| PDB | External Database | Details |
|---|---|---|
| Ala 77 | Arg 436 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ptr 418 | Tyr 444 | modified residue |
| Ptr 422 | Tyr 448 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 69384.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 267.2 | |
| All* | Total formula weight | 69652.0 |
