2HWI

HCV NS5B allosteric inhibitor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	RNA-directed RNA polymerase (NS5B) (p68)	polymer	576	64013.3	2	UniProt (P26663) Pfam (PF00998) In PDB	Hepatitis C virus
2	A, B	(2S)-({(5Z)-5-[(5-ETHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}AMINO)(4-FLUOROPHENYL)ACETIC ACID	non-polymer		374.4	2	Chemie (VRX)
3		water	water		18.0	400	Chemie (HOH)

Sequence modifications

A, B: 3 - 570 (UniProt: P26663)

PDB	External Database	Details
Ala -5	-	cloning artifact
Ser -4	-	cloning artifact
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
Val 329	Thr 2747	SEE REMARK 999
Ala 338	Val 2756	SEE REMARK 999
Gln 544	Arg 2962	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128026.6
Non-Polymers*	Number of molecules	2
	Total formula weight	748.8
All*	Total formula weight	128775.4

*Water molecules are not included.