2HWH
HCV NS5B allosteric inhibitor complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | RNA-directed RNA polymerase (NS5B) (p68) | polymer | 576 | 64013.3 | 2 | UniProt (P26663) Pfam (PF00998) In PDB | Hepatitis C virus | |
2 | A, B | 4-METHYL-N-{(5E)-5-[(5-METHYL-2-FURYL)METHYLENE]-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-2-YL}BENZENESULFONAMIDE | non-polymer | 362.4 | 2 | Chemie (RNA) | |||
3 | water | water | 18.0 | 188 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 570 (UniProt: P26663)
PDB | External Database | Details |
---|---|---|
Ala -5 | - | cloning artifact |
Ser -4 | - | cloning artifact |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
His 2 | - | expression tag |
Val 329 | Thr 2747 | SEE REMARK 999 |
Ala 338 | Val 2756 | SEE REMARK 999 |
Gln 544 | Arg 2962 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 128026.6 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 724.8 | |
All* | Total formula weight | 128751.5 |