2HW7
Crystal Structure of Mnk2-D228G in complex with Staurosporine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MAP kinase-interacting serine/threonine-protein kinase 2 | polymer | 316 | 35604.5 | 1 | UniProt (Q9HBH9) Pfam (PF00069) | Homo sapiens (human) | MAP kinase signal-integrating kinase 2, Mnk2 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (5279) PubChem (71203703) PubChem (42610657) PubChem (44259) PubChem (44299148) PubChem (49831000) PubChem (25322871) PubChem (28684983) PubChem (44120114) PubChem (44537813) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (451705) PubChem (73953205) PubChem (86306248) PubChem (358479) PubChem (5280487) PubChem (5459111) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (6419748) PubChem (9804568) PubChem (122130844) PubChem (12046017) PubChem (9937179) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 4 | D (A) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 72 - 385 (UniProt: Q9HBH9)
| PDB | External Database | Details |
|---|---|---|
| Gly 70 | - | cloning artifact |
| Ser 71 | - | cloning artifact |
| Gly 228 | Asp 228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35604.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 531.9 | |
| All* | Total formula weight | 36136.4 |
