2HW6

Crystal structure of Mnk1 catalytic domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	MAP kinase-interacting serine/threonine-protein kinase 1	polymer	307	34478.1	2	UniProt (Q9BUB5) Pfam (PF00069)	Homo sapiens (human)	MAP kinase signal-integrating kinase 1, Mnk1
2	C, D (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	E, F (A, B)	water	water		18.0	138	Chemie (HOH)

Sequence modifications

A, B: 37 - 341 (UniProt: Q9BUB5)

PDB	External Database	Details
Gly 35	-	cloning artifact
Ser 36	-	cloning artifact
-	Asp 165	SEE REMARK 999
-	Lys 166	SEE REMARK 999
-	Val 167	SEE REMARK 999
-	Ser 168	SEE REMARK 999
-	Leu 169	SEE REMARK 999
-	Cys 170	SEE REMARK 999
-	His 171	SEE REMARK 999
-	Leu 172	SEE REMARK 999
-	Gly 173	SEE REMARK 999
-	Trp 174	SEE REMARK 999
-	Ser 175	SEE REMARK 999
-	Ala 176	SEE REMARK 999
-	Met 177	SEE REMARK 999
-	Ala 178	SEE REMARK 999
-	Pro 179	SEE REMARK 999
-	Ser 180	SEE REMARK 999
-	Gly 181	SEE REMARK 999
-	Leu 182	SEE REMARK 999
-	Thr 183	SEE REMARK 999
-	Ala 184	SEE REMARK 999
-	Ala 185	SEE REMARK 999
-	Pro 186	SEE REMARK 999
-	Thr 187	SEE REMARK 999
-	Ser 188	SEE REMARK 999
-	Leu 189	SEE REMARK 999
-	Gly 190	SEE REMARK 999
-	Ser 191	SEE REMARK 999
-	Ser 192	SEE REMARK 999
-	Asp 193	SEE REMARK 999
-	Pro 194	SEE REMARK 999
-	Pro 195	SEE REMARK 999
-	Thr 196	SEE REMARK 999
-	Ser 197	SEE REMARK 999
-	Ala 198	SEE REMARK 999
-	Ser 199	SEE REMARK 999
-	Gln 200	SEE REMARK 999
-	Val 201	SEE REMARK 999
-	Ala 202	SEE REMARK 999
-	Gly 203	SEE REMARK 999
-	Thr 204	SEE REMARK 999
-	Thr 205	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	68956.3
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	69148.4

*Water molecules are not included.