2HVS

Structure of T4 RNA Ligase 2 with Nicked 5'-Adenylated nucleic acid duplex containing a 2'-deoxyribonucleotide at the nick

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (C, F)	5'-D(*AP*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*TP*TP*G)-3'	polymer	24	7440.8	2
2	B, E (D, G)	5'-D(*CP*AP*AP*TP*TP*GP*CP*GP*AP*C)-R(P*(OMC)P*C)-3'	polymer	12	3637.4	2
3	C, F (E, H)	5'-D(P*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*T)-3'	polymer	12	3646.4	2
4	G, H (A, B)	T4 RNA Ligase 2	polymer	335	37714.2	2	UniProt (P32277) Pfam (PF09414) Pfam (PF18043)	Enterobacteria phage T4
5	I, K, M (C, F, A)	2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		209.2	3	Chemie (BTB) PubChem (81462)
6	J, L (E, H)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505)
7	N, O, P, Q (C, E, A, B)	water	water		18.0	98	Chemie (HOH)

Sequence modifications

A, B: 1 - 334 (UniProt: P32277)

PDB	External Database	Details
Ser 0	-	cloning artifact
Gly 112	Cys 112	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	104877.5
Non-Polymers*	Number of molecules	5
	Total formula weight	1322.2
All*	Total formula weight	106199.7

*Water molecules are not included.