2HNZ
Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with PETT-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H | polymer | 534 | 61920.9 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | |
| 2 | B (B) | Reverse transcriptase/ribonuclease H | polymer | 422 | 49446.9 | 1 | UniProt (P03368) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) UniProt (by SIFTS) (P03366) | Human immunodeficiency virus 1 | |
| 3 | C, D (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | E (A) | 1-[2-(4-ETHOXY-3-FLUOROPYRIDIN-2-YL)ETHYL]-3-(5-METHYLPYRIDIN-2-YL)THIOUREA | non-polymer | 334.4 | 1 | Chemie (PC0) |
Sequence modifications
A: 4 - 537 (UniProt: P04585)
B: 7 - 428 (UniProt: P03368)
| PDB | External Database | Details |
|---|---|---|
| Lys 138 | Glu 724 | engineered mutation |
| Csd 280 | Cys 866 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Lys 138 | Glu 736 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111367.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 524.4 | |
| All* | Total formula weight | 111892.1 |
