2HND
Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with Nevirapine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H | polymer | 534 | 61920.7 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus 1 | |
| 2 | B (B) | Reverse transcriptase/ribonuclease H | polymer | 422 | 49446.8 | 1 | UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) UniProt (by SIFTS) (P03367) | Human immunodeficiency virus 1 | |
| 3 | C, D, E (A) | PHOSPHATE ION | non-polymer | 95.0 | 3 | Chemie (PO4) | |||
| 4 | F (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | G (A) | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE | non-polymer | 266.3 | 1 | Chemie (NVP) | |||
| 6 | H, I (A, B) | water | water | 18.0 | 80 | Chemie (HOH) |
Sequence modifications
A: 4 - 537 (UniProt: P04585)
B: 7 - 428 (UniProt: P04585)
| PDB | External Database | Details |
|---|---|---|
| Glu 101 | Lys 687 | engineered mutation |
| Csd 280 | Cys 866 | modified residue |
| PDB | External Database | Details |
|---|---|---|
| Glu 101 | Lys 687 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111367.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 575.5 | |
| All* | Total formula weight | 111943.0 |
