2HLE
Structural and biophysical characterization of the EPHB4-EPHRINB2 protein protein interaction and receptor specificity.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Ephrin type-B receptor 4 | polymer | 188 | 21354.2 | 1 | UniProt (P54760) Pfam (PF01404) In PDB | Homo sapiens (human) | Tyrosine-protein kinase receptor HTK, EPHB4 |
2 | B | Ephrin-B2 | polymer | 138 | 15787.1 | 1 | UniProt (P52799) Pfam (PF00812) In PDB | Homo sapiens (human) | EPH-related receptor tyrosine kinase ligand 5, LERK-5, HTK ligand, HTK-L, EPHRINB2 |
3 | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 17 - 196 (UniProt: P54760)
B: 31 - 168 (UniProt: P52799)
PDB | External Database | Details |
---|---|---|
Ala 9 | - | cloning artifact |
Gly 10 | - | cloning artifact |
His 11 | - | expression tag |
His 12 | - | expression tag |
His 13 | - | expression tag |
His 14 | - | expression tag |
His 15 | - | expression tag |
His 16 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Arg 106 | Lys 103 | conflict |
Val 111 | Ile 108 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 37141.3 | |
All* | Total formula weight | 37141.3 |