2HIJ
Crystal Structure of P14 Alanine Variant of Antithrombin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (I) | Antithrombin-III | polymer | 432 | 49042.0 | 1 | UniProt (P01008) Pfam (PF00079) | Homo sapiens (human) | ATIII |
| 2 | B (L) | Antithrombin-III | polymer | 432 | 49101.0 | 1 | UniProt (P01008) Pfam (PF00079) | Homo sapiens (human) | ATIII |
| 3 | C (A) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 4 | D (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E, G, H, I (I, L) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 6 | F, J (I, L) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | K, L (I, L) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
I: 1 - 432 (UniProt: P01008)
| PDB | External Database | Details |
|---|---|---|
| Ala 135 | Asn 167 | engineered mutation |
| Ala 380 | Ser 412 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 98143.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1010.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1069.0 | |
| All* | Total formula weight | 100223.0 |
