2HHA
The structure of DPP4 in complex with an oxadiazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hypothetical protein DPP4 | polymer | 728 | 84476.6 | 2 | UniProt (Q53TN1) Pfam (PF00930) Pfam (PF00326) UniProt (by SIFTS) (P27487) | Homo sapiens (human) | |
| 2 | C, F (C, F) | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G07375KG) | |||
| 3 | D, E, G, H, I... (D, E, G, H, I...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
| 4 | L, M, N, Q, R... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 5 | O (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | P, T (A, B) | (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE | non-polymer | 378.4 | 2 | Chemie (3TP) | |||
| 7 | U, V (A, B) | water | water | 18.0 | 890 | Chemie (HOH) |
Sequence modifications
A, B: 39 - 766 (UniProt: Q53TN1)
| PDB | External Database | Details |
|---|---|---|
| Thr 39 | Ser 39 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 168953.3 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 3819.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2107.1 | |
| All* | Total formula weight | 174880.0 |
