2HCA
Crystal structure of bovine lactoferrin C-lobe liganded with Glucose at 2.8 A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Lactotransferrin (Lactoferrin) | polymer | 345 | 37655.5 | 1 | UniProt (P24627) Pfam (PF00405) In PDB | Bos taurus (cattle) | |
| 2 | B | beta-D-mannopyranose-(1-4)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G09791GF) | |||
| 3 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D | beta-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G38475OD) | |||
| 5 | A | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
| 6 | A | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
| 7 | A | CARBONATE ION | non-polymer | 60.0 | 1 | Chemie (CO3) | |||
| 8 | A | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 9 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 10 | water | water | 18.0 | 227 | Chemie (HOH) |
Sequence modifications
A: 342 - 686 (UniProt: P24627)
| PDB | External Database | Details |
|---|---|---|
| Lys 565 | Asn 584 | engineered mutation |
| Glu 608 | Lys 627 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37655.5 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 2408.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 522.9 | |
| All* | Total formula weight | 40586.6 |
