2HBZ

Crystal structure of human caspase-1 (Arg286->Ala, Glu390->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)

Replaces:  2FQV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Caspase-1	polymer	178	19783.7	1	UniProt (P29466) Pfam (PF00656) In PDB	Homo sapiens (human)
2	B	Caspase-1	polymer	88	10200.7	1	UniProt (P29466) Pfam (PF00656) In PDB	Homo sapiens (human)
3	C	PHQ-VAD-fluoromethylketone inhibitor	polymer	5	471.9	1	BIRD (PRD_000338)		Z-VAD-FMK
4		water	water		18.0	183	Chemie (HOH)

Sequence modifications

A: 120 - 297 (UniProt: P29466)

PDB	External Database	Details
Ala 286	Arg 286	engineered mutation

B: 317 - 404 (UniProt: P29466)

PDB	External Database	Details
Ala 390	Glu 390	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	30456.3
All*	Total formula weight	30456.3

*Water molecules are not included.