2HBY
Crystal structure of human caspase-1 (Glu390->Ala) in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Replaces: 2FQUEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Caspase-1 | polymer | 178 | 19869.8 | 1 | UniProt (P29466) Pfam (PF00656) | Homo sapiens (human) | |
| 2 | B (B) | Caspase-1 | polymer | 88 | 10200.7 | 1 | UniProt (P29466) Pfam (PF00656) | Homo sapiens (human) | |
| 3 | C (C) | N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide | polymer | 5 | 471.9 | 1 | BIRD (PRD_000338) | ||
| 4 | D, E, F (A, B, C) | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
B: 317 - 404 (UniProt: P29466)
| PDB | External Database | Details |
|---|---|---|
| Ala 390 | Glu 390 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 30542.5 | |
| All* | Total formula weight | 30542.5 |
