2HBT
Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Egl nine homolog 1 | polymer | 247 | 27832.7 | 1 | UniProt (Q9GZT9) Pfam (PF13640) | Homo sapiens (human) | Hypoxia-inducible factor prolyl hydroxylase 2, HIF-prolyl hydroxylase 2, HIF-PH2, HPH-2, Prolyl hydroxylase domain-containing protein 2, PHD2, SM-20 |
| 2 | B (A) | FE (II) ION | non-polymer | 55.8 | 1 | Chemie (FE2) | |||
| 3 | C (A) | N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE | non-polymer | 280.7 | 1 | Chemie (UN9) | |||
| 4 | D (A) | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A: 188 - 426 (UniProt: Q9GZT9)
| PDB | External Database | Details |
|---|---|---|
| Met 180 | - | cloning artifact |
| Ala 181 | - | cloning artifact |
| His 182 | - | cloning artifact |
| His 183 | - | cloning artifact |
| His 184 | - | cloning artifact |
| His 185 | - | cloning artifact |
| His 186 | - | cloning artifact |
| His 187 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27832.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 336.5 | |
| All* | Total formula weight | 28169.2 |
