2H9V
Structural basis for induced-fit binding of Rho-kinase to the inhibitor Y27632
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Rho-associated protein kinase 2 | polymer | 402 | 45776.0 | 1 | UniProt (Q28021) Pfam (PF00069) | Bos taurus (cattle) | Rho-kinase, Rho-associated, coiled- coil-containing protein kinase 2, p164 ROCK-2 |
| 2 | B (A) | (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE | non-polymer | 247.3 | 1 | Chemie (Y27) | |||
| 3 | C (A) | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 18 - 417 (UniProt: Q28021)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | cloning artifact |
| Ala 17 | - | cloning artifact |
| Ser 52 | Pro 52 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45776.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 247.3 | |
| All* | Total formula weight | 46023.4 |
