2H5K
Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Growth factor receptor-bound protein 2 | polymer | 116 | 13687.5 | 2 | UniProt (P62993) Pfam (PF00017) | Homo sapiens (human) | Adapter protein GRB2, SH2/SH3 adapter GRB2, Protein Ash |
| 2 | C (C) | Shc-Derived Ligand | polymer | 5 | 498.4 | 1 | |||
| 3 | D (B) | CACODYLATE ION | non-polymer | 137.0 | 1 | Chemie (CAC) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A, B: 53 - 162 (UniProt: P62993)
| PDB | External Database | Details |
|---|---|---|
| His 163 | - | expression tag |
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| His 166 | - | expression tag |
| His 167 | - | expression tag |
| His 168 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 27873.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 137.0 | |
| All* | Total formula weight | 28010.4 |
