2H5K

Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Growth factor receptor-bound protein 2	polymer	116	13687.5	2	UniProt (P62993) Pfam (PF00017) In PDB	Homo sapiens (human)	Adapter protein GRB2, SH2/SH3 adapter GRB2, Protein Ash
2	C	Shc-Derived Ligand	polymer	5	498.4	1
3	B	CACODYLATE ION	non-polymer		137.0	1	Chemie (CAC)
4		water	water		18.0	9	Chemie (HOH)

Sequence modifications

A, B: 53 - 162 (UniProt: P62993)

PDB	External Database	Details
His 163	-	EXPRESSION TAG
His 164	-	EXPRESSION TAG
His 165	-	EXPRESSION TAG
His 166	-	EXPRESSION TAG
His 167	-	EXPRESSION TAG
His 168	-	EXPRESSION TAG

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	27873.4
Non-Polymers*	Number of molecules	1
	Total formula weight	137.0
All*	Total formula weight	28010.4

*Water molecules are not included.