2H5G
Crystal structure of human pyrroline-5-carboxylate synthetase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Delta 1-pyrroline-5-carboxylate synthetase | polymer | 463 | 51737.6 | 2 | UniProt (P54886) Pfam (PF00171) | Homo sapiens (human) | pyrroline-5-carboxylate synthetase isoform 1, PYCS, P5CS, Aldehyde dehydrogenase 18 family member A1 |
| 2 | C, D, E, F, G... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 3 | I, J (A, B) | water | water | 18.0 | 277 | Chemie (HOH) |
Sequence modifications
A, B: 362 - 795 (UniProt: P54886)
| PDB | External Database | Details |
|---|---|---|
| Mse 333 | - | initiating methionine |
| His 334 | - | expression tag |
| His 335 | - | expression tag |
| His 336 | - | expression tag |
| His 337 | - | expression tag |
| His 338 | - | expression tag |
| His 339 | - | expression tag |
| Ser 340 | - | cloning artifact |
| Ser 341 | - | cloning artifact |
| Gly 342 | - | cloning artifact |
| Val 343 | - | cloning artifact |
| Asp 344 | - | cloning artifact |
| Leu 345 | - | cloning artifact |
| Gly 346 | - | cloning artifact |
| Thr 347 | - | cloning artifact |
| Glu 348 | - | cloning artifact |
| Asn 349 | - | cloning artifact |
| Leu 350 | - | cloning artifact |
| Tyr 351 | - | cloning artifact |
| Phe 352 | - | cloning artifact |
| Gln 353 | - | cloning artifact |
| Ser 354 | - | cloning artifact |
| Mse 355 | - | cloning artifact |
| Val 356 | - | cloning artifact |
| Lys 357 | - | cloning artifact |
| Pro 358 | - | cloning artifact |
| Ala 359 | - | cloning artifact |
| Gly 360 | - | cloning artifact |
| Pro 361 | - | cloning artifact |
| Mse 369 | Met 369 | modified residue |
| Mse 376 | Met 376 | modified residue |
| Mse 551 | Met 551 | modified residue |
| Mse 577 | Met 577 | modified residue |
| Mse 586 | Met 586 | modified residue |
| Mse 636 | Met 636 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 103475.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 576.4 | |
| All* | Total formula weight | 104051.6 |
