2H2Q
Crystal structure of Trypanosoma cruzi Dihydrofolate Reductase-Thymidylate synthase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 521 | 58904.1 | 2 | UniProt (Q27793) Pfam (PF00186) Pfam (PF00303) | Trypanosoma cruzi | |
| 2 | C, E (A, B) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
| 3 | D, F (A, B) | 2'-DEOXYURIDINE-5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (DU) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 307 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 521 (UniProt: Q27793)
| PDB | External Database | Details |
|---|---|---|
| Arg 32 | His 32 | SEE REMARK 999 |
| Val 55 | Leu 55 | SEE REMARK 999 |
| Gln 137 | Arg 137 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 117808.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2103.2 | |
| All* | Total formula weight | 119911.3 |
