2H03
Structural studies of protein tyrosine phosphatase beta catalytic domain in complex with inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein tyrosine phosphatase, receptor type, B, | polymer | 291 | 33780.3 | 1 | UniProt (Q3MIV7) Pfam (PF00102) UniProt (by SIFTS) (P23467) In PDB | Homo sapiens (human) | |
| 2 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A | (4-{4-[(TERT-BUTOXYCARBONYL)AMINO]-2,2-BIS(ETHOXYCARBONYL)BUTYL}PHENYL)SULFAMIC ACID | non-polymer | 488.6 | 1 | Chemie (3UN) | |||
| 5 | water | water | 18.0 | 202 | Chemie (HOH) |
Sequence modifications
A: 1676 - 1970 (UniProt: Q3MIV7)
| PDB | External Database | Details |
|---|---|---|
| Ser 1675 | - | cloning artifact |
| - | Asn 1748 | deletion |
| - | Val 1749 | deletion |
| - | Asp 1750 | deletion |
| - | Asp 1751 | deletion |
| - | Asp 1752 | deletion |
| Gly 1748 | Pro 1753 | engineered mutation |
| Gly 1749 | Cys 1754 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33780.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 608.1 | |
| All* | Total formula weight | 34388.4 |
