2GTP
Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Guanine nucleotide-binding protein G(i), alpha-1 subunit | polymer | 323 | 37031.2 | 2 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | C, D (C, D) | Regulator of G-protein signaling 1 | polymer | 145 | 16575.8 | 2 | UniProt (Q08116) Pfam (PF00615) | Homo sapiens (human) | RGS1, Early response protein 1R20, B-cell activation protein BL34 |
| 3 | E, H (A, B) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) | |||
| 4 | F, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | G, J (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
C, D: 50 - 192 (UniProt: Q08116)
| PDB | External Database | Details |
|---|---|---|
| Ser 48 | - | cloning artifact |
| Met 49 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 107214.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1141.0 | |
| All* | Total formula weight | 108355.0 |
