2GTP
Crystal structure of the heterodimeric complex of human RGS1 and activated Gi alpha 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Guanine nucleotide-binding protein G(i), alpha-1 subunit | polymer | 323 | 37031.2 | 2 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | C, D (C, D) | Regulator of G-protein signaling 1 | polymer | 145 | 16575.8 | 2 | UniProt (Q08116) Pfam (PF00615) | Homo sapiens (human) | RGS1, Early response protein 1R20, B-cell activation protein BL34 |
| 3 | E, H (A, B) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 2 | Chemie (ALF) PubChem (5311325) | |||
| 4 | F, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | G, J (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 6 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 134 | Chemie (HOH) |
Sequence modifications
C, D: 50 - 192 (UniProt: Q08116)
| PDB | External Database | Details |
|---|---|---|
| Ser 48 | - | cloning artifact |
| Met 49 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 107214.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1141.0 | |
| All* | Total formula weight | 108355.0 |
