2GS7
Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Epidermal growth factor receptor | polymer | 330 | 37621.5 | 2 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Receptor tyrosine-protein kinase ErbB-1 |
| 2 | C, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, E, F, G, H... (A, B) | IODIDE ION | non-polymer | 126.9 | 11 | Chemie (IOD) | |||
| 4 | I, Q (A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 5 | R, S (A, B) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A, B: 672 - 998 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 669 | - | cloning artifact |
| Ala 670 | - | cloning artifact |
| Met 671 | - | cloning artifact |
| Arg 924 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75243.0 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2456.9 | |
| All* | Total formula weight | 77700.0 |
