2GS6
Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Epidermal growth factor receptor | polymer | 330 | 37563.5 | 1 | UniProt (Q9H2C9) Pfam (PF07714) UniProt (by SIFTS) (P00533) In PDB | Homo sapiens (human) | Receptor tyrosine-protein kinase ErbB-1 |
| 2 | B | Peptide | polymer | 13 | 1544.7 | 1 | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | B | THIOPHOSPHORIC ACID O-((ADENOSYL-PHOSPHO)PHOSPHO)-S-ACETAMIDYL-DIESTER | non-polymer | 580.3 | 1 | Chemie (112) | |||
| 5 | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A: 672 - 998 (UniProt: Q9H2C9)
| PDB | External Database | Details |
|---|---|---|
| Gly 669 | - | cloning artifact |
| Ala 670 | - | cloning artifact |
| Met 671 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 39108.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 615.8 | |
| All* | Total formula weight | 39723.9 |
