2GNH
PKA five fold mutant model of Rho-kinase with H1152P
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase, alpha-catalytic subunit | polymer | 350 | 40775.5 | 1 | UniProt (P00517) Pfam (PF00069) | Bos taurus (cattle) | PKA C-alpha |
| 2 | B (I) | cAMP-dependent protein kinase inhibitor alpha | polymer | 20 | 2226.4 | 1 | UniProt (P61926) | PKI-alpha, cAMP-dependent protein kinase inhibitor, muscle/brain isoform | |
| 3 | C, D (A) | (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE | non-polymer | 319.4 | 2 | Chemie (H52) | |||
| 4 | E, F (A, I) | water | water | 18.0 | 232 | Chemie (HOH) |
Sequence modifications
A: 1 - 350 (UniProt: P00517)
| PDB | External Database | Details |
|---|---|---|
| Sep 10 | Ser 10 | modified residue |
| Ile 49 | Leu 49 | engineered mutation |
| Met 123 | Val 123 | engineered mutation |
| Asp 127 | Glu 127 | engineered mutation |
| Lys 181 | Gln 181 | engineered mutation |
| Ala 183 | Thr 183 | engineered mutation |
| Tpo 197 | Thr 197 | modified residue |
| Sep 338 | Ser 338 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43001.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 638.8 | |
| All* | Total formula weight | 43640.7 |
