2GN8

Crystal structure of UDP-GlcNAc inverting 4,6-dehydratase in complex with NADP and UDP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	UDP-GlcNAc C6 dehydratase	polymer	344	38724.7	2	UniProt (O25511) Pfam (PF02719)	Helicobacter pylori	flaA1 protein
2	C, F (A, B)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010)
3	D, G (A, B)	URIDINE-5'-DIPHOSPHATE	non-polymer		404.2	2	Chemie (UDP) PubChem (1158) PubChem (6031) PubChem (25323044) PubChem (25323048) PubChem (44298965) PubChem (53486216) PubChem (3084486) PubChem (60098857) PubChem (57448939) PubChem (6101632) PubChem (6604175) PubChem (91746160) PubChem (92332560) PubChem (92332561) PubChem (92332562) PubChem (92332563) PubChem (11811538) PubChem (93088131) PubChem (93630083) PubChem (12049241)
4	E (A)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES) PubChem (4478249)
5	H, I (A, B)	water	water		18.0	288	Chemie (HOH)

Sequence modifications

A, B: 1 - 333 (UniProt: O25511)

PDB	External Database	Details
Met -10	-	cloning artifact
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	cloning artifact
Ser -2	-	cloning artifact
Met -1	-	cloning artifact
Ser 0	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	77449.4
Non-Polymers*	Number of molecules	5
	Total formula weight	2490.4
All*	Total formula weight	79939.8

*Water molecules are not included.