2GK6
Structural and Functional insights into the human Upf1 helicase core
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Regulator of nonsense transcripts 1 | polymer | 624 | 70056.4 | 2 | UniProt (Q92900) Pfam (PF18141) Pfam (PF13086) Pfam (PF13087) | Homo sapiens (human) | ATP-dependent helicase RENT1, Nonsense mRNA reducing factor 1, NORF1, Up-frameshift suppressor 1 homolog, hUpf1 |
| 2 | C, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, G (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | E, H (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 233 | Chemie (HOH) |
Sequence modifications
A, B: 295 - 914 (UniProt: Q92900)
| PDB | External Database | Details |
|---|---|---|
| Pro 291 | - | cloning artifact |
| Leu 292 | - | cloning artifact |
| Gly 293 | - | cloning artifact |
| Ser 294 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 140112.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1093.0 | |
| All* | Total formula weight | 141205.8 |
