2GFS
P38 Kinase Crystal Structure in complex with RO3201195
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mitogen-Activated Protein Kinase 14 | polymer | 372 | 42748.7 | 1 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (human) | Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting protein 2; MAP kinase MXI2; SAPK2A |
| 2 | A | [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE | non-polymer | 371.4 | 1 | Chemie (PQB) | |||
| 3 | water | water | 18.0 | 293 | Chemie (HOH) |
Sequence modifications
A: 2 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Met -11 | - | insertion |
| Arg -10 | - | insertion |
| Gly -9 | - | insertion |
| Ser -8 | - | insertion |
| His -7 | - | insertion |
| His -6 | - | insertion |
| His -5 | - | insertion |
| His -4 | - | insertion |
| His -3 | - | insertion |
| His -2 | - | insertion |
| Gly -1 | - | insertion |
| Ser 0 | - | insertion |
| Met 1 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42748.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 371.4 | |
| All* | Total formula weight | 43120.1 |
