2GDE
Thrombin in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Thrombin light chain | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | |
| 2 | B (H) | Thrombin heavy chain | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C (D) | Hirudin | polymer | 10 | 1291.3 | 1 | UniProt (P28504) UniProt (by SIFTS) (P01050) | Hirudo medicinalis | |
| 4 | D (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | E (H) | (R)-3-((2S,3R)-1-((2S,3AR,5S,6S,7AS)-2-(2-(1-CARBAMIMIDOYL-2,5-DIHYDRO-1H-PYRROL-3-YL)ETHYLCARBAMOYL)-5,6-DIHYDROXYOCTA HYDRO-1H-INDOL-1-YL)-3-CHLORO-4-METHYL-1-OXOPENTAN-2-YLAMINO)-2-METHOXY-3-OXOPROPYL HYDROGEN SULFATE | non-polymer | 667.2 | 1 | Chemie (SN3) | |||
| 6 | F, G (L, H) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
D: 355 - 364 (UniProt: P28504)
| PDB | External Database | Details |
|---|---|---|
| Gly 361 | Glu 61 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 35168.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 690.2 | |
| All* | Total formula weight | 35858.3 |
