2G76
Crystal structure of human 3-phosphoglycerate dehydrogenase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | D-3-phosphoglycerate dehydrogenase | polymer | 335 | 36102.4 | 2 | UniProt (O43175) Pfam (PF00389) Pfam (PF02826) | Homo sapiens (human) | 3-PGDH |
| 2 | C, E (A, B) | D-MALATE | non-polymer | 134.1 | 2 | Chemie (MLT) | |||
| 3 | D, F (A, B) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 2 | Chemie (NAD) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 278 | Chemie (HOH) |
Sequence modifications
A, B: 3 - 314 (UniProt: O43175)
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | initiating methionine |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| His -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| Ser -13 | - | cloning artifact |
| Ser -12 | - | cloning artifact |
| Gly -11 | - | cloning artifact |
| Val -10 | - | cloning artifact |
| Asp -9 | - | cloning artifact |
| Leu -8 | - | cloning artifact |
| Gly -7 | - | cloning artifact |
| Thr -6 | - | cloning artifact |
| Glu -5 | - | cloning artifact |
| Asn -4 | - | cloning artifact |
| Leu -3 | - | cloning artifact |
| Tyr -2 | - | cloning artifact |
| Phe -1 | - | cloning artifact |
| Gln 0 | - | cloning artifact |
| Ser 1 | - | cloning artifact |
| Met 2 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72204.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1595.0 | |
| All* | Total formula weight | 73799.9 |
