2G76

Crystal structure of human 3-phosphoglycerate dehydrogenase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	D-3-phosphoglycerate dehydrogenase	polymer	335	36102.4	2	UniProt (O43175) Pfam (PF00389) Pfam (PF02826) In PDB	Homo sapiens (human)	3-PGDH
2	A, B	D-MALATE	non-polymer		134.1	2	Chemie (MLT)
3	A, B	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	2	Chemie (NAD)
4		water	water		18.0	278	Chemie (HOH)

Sequence modifications

A, B: 3 - 314 (UniProt: O43175)

PDB	External Database	Details
Met -20	-	initiating methionine
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
Ser -13	-	cloning artifact
Ser -12	-	cloning artifact
Gly -11	-	cloning artifact
Val -10	-	cloning artifact
Asp -9	-	cloning artifact
Leu -8	-	cloning artifact
Gly -7	-	cloning artifact
Thr -6	-	cloning artifact
Glu -5	-	cloning artifact
Asn -4	-	cloning artifact
Leu -3	-	cloning artifact
Tyr -2	-	cloning artifact
Phe -1	-	cloning artifact
Gln 0	-	cloning artifact
Ser 1	-	cloning artifact
Met 2	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	72204.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1595.0
All*	Total formula weight	73799.9

*Water molecules are not included.