2G6D
Human cathepsin S mutant with vinyl sulfone inhibitor CRA-14009
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | cathepsin S | polymer | 217 | 24077.1 | 1 | UniProt (P25774) Pfam (PF00112) In PDB | Homo sapiens (human) | |
| 2 | A | N-[(1S)-1-[({(1S)-3-PHENYL-1-[2-(PHENYLSULFONYL)ETHYL]PROPYL}AMINO)CARBONYL]-3-(PHENYLSULFONYL)PROPYL]MORPHOLINE-4-CARBOXAMIDE | non-polymer | 641.8 | 1 | Chemie (MQQ) | |||
| 3 | water | water | 18.0 | 78 | Chemie (HOH) |
Sequence modifications
A: 1 - 211 (UniProt: P25774)
| PDB | External Database | Details |
|---|---|---|
| Arg 108 | Ser 225 | engineered mutation |
| Lys 184 | Glu 307 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24077.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 641.8 | |
| All* | Total formula weight | 24718.9 |
