2G2I
A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Abl Tyrosine Kinase | polymer | 287 | 33182.0 | 2 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (human) | p150, c- ABL, Abelson murine leukemia viral oncogene homolog 1 |
| 2 | C, D (C, D) | ATP-Peptide Conjugate | polymer | 13 | 1528.7 | 2 | |||
| 3 | E, F (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) |
Sequence modifications
A, B: 229 - 512 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 226 | - | cloning artifact |
| His 227 | - | cloning artifact |
| Met 228 | - | cloning artifact |
| Pro 396 | His 396 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 69421.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 854.4 | |
| All* | Total formula weight | 70275.6 |
