2G2H
A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Abl Tyrosine | polymer | 287 | 33182.0 | 2 | UniProt (P00519) Pfam (PF07714) | Homo sapiens (human) | p150, c- ABL, Abelson murine leukemia viral oncogene homolog 1 |
| 2 | C, D (A, B) | 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE | non-polymer | 427.3 | 2 | Chemie (P16) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 413 | Chemie (HOH) |
Sequence modifications
A, B: 248 - 531 (UniProt: P00519)
| PDB | External Database | Details |
|---|---|---|
| Gly 245 | - | cloning artifact |
| His 246 | - | cloning artifact |
| Met 247 | - | cloning artifact |
| Pro 415 | His 396 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66363.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 854.6 | |
| All* | Total formula weight | 67218.5 |
