2FZI
New Insights into DHFR Interactions: Analysis of Pneumocystis carinii and Mouse DHFR Complexes with NADPH and Two Highly Potent Trimethoprim Derivatives
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydrofolate reductase | polymer | 206 | 23918.5 | 1 | UniProt (P16184) Pfam (PF00186) In PDB | Pneumocystis carinii | |
| 2 | A | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 3 | A | 2,4-DIAMINO-5-[3',4'-DIMETHOXY-5'-(5-CARBOXYL-1-PENTYNYL)]BENZYL PYRIMIDINE | non-polymer | 370.4 | 1 | Chemie (DH3) | |||
| 4 | water | water | 18.0 | 171 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23918.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1115.8 | |
| All* | Total formula weight | 25034.4 |
