2FWY
Structure of human Hsp90-alpha bound to the potent water soluble inhibitor PU-H64
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Heat shock protein HSP 90-alpha | polymer | 256 | 28773.1 | 1 | GenBank (61656605) Pfam (PF13589) UniProt (by SIFTS) (P07900) In PDB | Homo sapiens (human) | HSP90 protein |
2 | A | 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE | non-polymer | 465.4 | 1 | Chemie (H64) | |||
3 | water | water | 18.0 | 290 | Chemie (HOH) |
Sequence modifications
A: 1 - 236 (GenBank: 61656605)
PDB | External Database | Details |
---|---|---|
Met -19 | - | cloning artifact |
Gly -18 | - | cloning artifact |
Ser -17 | - | cloning artifact |
Ser -16 | - | cloning artifact |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | cloning artifact |
Ser -8 | - | cloning artifact |
Gly -7 | - | cloning artifact |
Leu -6 | - | cloning artifact |
Val -5 | - | cloning artifact |
Pro -4 | - | cloning artifact |
Arg -3 | - | cloning artifact |
Gly -2 | - | cloning artifact |
Ser -1 | - | cloning artifact |
His 0 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 28773.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 465.4 | |
All* | Total formula weight | 29238.5 |