2FTD

Crystal structure of Cathepsin K complexed with 7-Methyl-Substituted Azepan-3-one compound

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cathepsin K	polymer	215	23523.5	2	UniProt (P61277) Pfam (PF00112)	Macaca mulatta (rhesus monkey)
2	C, D (A, B)	N-[(1S)-1-({[(3S,4S,7R)-3-HYDROXY-7-METHYL-1-(PYRIDIN-2-YLSULFONYL)-2,3,4,7-TETRAHYDRO-1H-AZEPIN-4-YL]AMINO}CARBONYL)-3-METHYLBUTYL]-1-BENZOFURAN-2-CARBOXAMIDE	non-polymer		540.6	2	Chemie (ILI)
3	E, F (A, B)	water	water		18.0	193	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	47047.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1081.3
All*	Total formula weight	48128.2

*Water molecules are not included.