2FST

mitogen activated protein kinase p38alpha (D176A+F327L) activating mutant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (X)	Mitogen-activated protein kinase 14	polymer	367	42165.1	1	UniProt (Q16539) Pfam (PF00069)	Homo sapiens (human)	Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
2	B, C, D (X)	octyl beta-D-glucopyranoside	non-polymer		292.4	3	Chemie (BOG)
3	E (X)	water	water		18.0	435	Chemie (HOH)

Sequence modifications

X: 2 - 360 (UniProt: Q16539)

PDB	External Database	Details
Met -6	-	expression tag
Ala -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Ala 176	Asp 175	engineered mutation
Leu 327	Phe 326	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42165.1
Non-Polymers*	Number of molecules	3
	Total formula weight	877.1
All*	Total formula weight	43042.2

*Water molecules are not included.