2FSM
mitogen activated protein kinase p38alpha (D176A+F327S) activating mutant form-B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Mitogen-activated protein kinase 14 | polymer | 367 | 42139.0 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (human) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
| 2 | B (X) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 1 | Chemie (BOG) | |||
| 3 | C (X) | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
X: 2 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | expression tag |
| Ala -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
| Ala 176 | Asp 175 | engineered mutation |
| Ser 327 | Phe 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42139.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 292.4 | |
| All* | Total formula weight | 42431.4 |
