2FSL

mitogen activated protein kinase p38alpha (D176A+F327S) activating mutant form-A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	X	Mitogen-activated protein kinase 14	polymer	367	42139.0	1	UniProt (Q16539) Pfam (PF00069) In PDB	Homo sapiens (human)	Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A
2	X	octyl beta-D-glucopyranoside	non-polymer		292.4	1	Chemie (BOG)
3		water	water		18.0	207	Chemie (HOH)

Sequence modifications

X: 2 - 360 (UniProt: Q16539)

PDB	External Database	Details
Met -6	-	expression tag
Ala -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Ala 176	Asp 175	engineered mutation
Ser 327	Phe 326	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42139.0
Non-Polymers*	Number of molecules	1
	Total formula weight	292.4
All*	Total formula weight	42431.4

*Water molecules are not included.