2FRD

Structure of Transhydrogenase (dI.S138A.NADH)2(dIII.NADPH)1 asymmetric complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NAD(P) transhydrogenase subunit alpha part 1	polymer	384	40308.8	2	UniProt (Q60164) Pfam (PF05222) Pfam (PF01262) UniProt (by SIFTS) (Q2RSB2)	Rhodospirillum rubrum	Pyridine nucleotide transhydrogenase subunit alpha 1, Nicotinamide nucleotide transhydrogenase subunit alpha 1, Proton-translocating transhydrogenase component 1, dI
2	C (C)	NAD(P) transhydrogenase subunit beta	polymer	203	21485.5	1	UniProt (Q59765) UniProt (by SIFTS) (P0C188)	Rhodospirillum rubrum	Pyridine nucleotide transhydrogenase subunit beta, Nicotinamide nucleotide transhydrogenase subunit beta, Proton-translocating transhydrogenase NADPH, -binding component, dIII
3	D, E (A, B)	1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE	non-polymer		665.4	2	Chemie (NAI) PubChem (16219774) PubChem (928) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (94865921) PubChem (94865923) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (124432988) PubChem (140875346) PubChem (11250888) PubChem (12309341) PubChem (124934831) PubChem (124934833) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (129607000) PubChem (129628338) PubChem (146167236) PubChem (162951602) PubChem (174084875)
4	F (C)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	1	Chemie (NDP)
5	G (B)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 1 - 384 (UniProt: Q60164)

PDB	External Database	Details
Ala 138	Ser 138	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	102103.1
Non-Polymers*	Number of molecules	3
	Total formula weight	2076.3
All*	Total formula weight	104179.4

*Water molecules are not included.