2FOS
Human Carbonic Anhydrase II complexed with two-prong inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic Anhydrase II | polymer | 260 | 29503.7 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (human) | Carbonic anhydrase II, Carbonate dehydratase II, CA-II, Carbonic anhydrase C |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C, D (A) | COPPER (II) ION | non-polymer | 63.5 | 2 | Chemie (CU) | |||
| 4 | E, F (A) | {1-[4-(AMINOSULFONYL)PHENYL]-11-[(CARBOXY-KAPPAO)METHYL]-1-OXO-5,8-DIOXA-2,11-DIAZATRIDECAN-13-OATO(2-)-KAPPAO~13~}COPPER | non-polymer | 509.0 | 2 | Chemie (B17) | |||
| 5 | G (A) | water | water | 18.0 | 326 | Chemie (HOH) |
Sequence modifications
A: 2 - 260 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Cmh 206 | Cys 204 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29503.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1210.5 | |
| All* | Total formula weight | 30714.2 |
