2FNS
Crystal structure of wild-type inactive (D25N) HIV-1 protease complexed with wild-type HIV-1 NC-p1 substrate.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Protease | polymer | 99 | 10800.8 | 2 | UniProt (O38716) Pfam (PF00077) UniProt (by SIFTS) (P03369) In PDB | Human immunodeficiency virus 1 | Retropepsin, PR |
2 | P | NC-P1 SUBSTRATE PEPTIDE | polymer | 10 | 1162.3 | 1 | |||
3 | A, B | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
4 | B | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
5 | water | water | 18.0 | 109 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: O38716)
PDB | External Database | Details |
---|---|---|
Lys 7 | Gln 7 | engineered mutation |
Asn 25 | Asp 25 | engineered mutation |
Val 64 | Ile 64 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 22763.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 213.1 | |
All* | Total formula weight | 22977.0 |