2FME

Crystal structure of the mitotic kinesin eg5 (ksp) in complex with mg-adp and (r)-4-(3-hydroxyphenyl)-n,n,7,8-tetramethyl-3,4-dihydroisoquinoline-2(1h)-carboxamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Kinesin-like protein KIF11	polymer	368	41055.6	2	UniProt (P52732) Pfam (PF00225) In PDB	Homo sapiens (human)	Kinesin-related motor protein Eg5, Kinesin-like spindle protein HKSP, Thyroid receptor interacting protein 5, TRIP5, Kinesin-like protein 1
2	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
3	A, B	(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE	non-polymer		324.4	2	Chemie (3QC)
4	A, B	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	2	Chemie (ADP)
5		water	water		18.0	178	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	82111.2
Non-Polymers*	Number of molecules	6
	Total formula weight	1551.8
All*	Total formula weight	83663.0

*Water molecules are not included.